AGP
The Autism Genome Project
"Investigating the genetic basis of autism"

AGP Research: Current Project

 

1. AGP Phase 2 project (2007-):

1.1 Publications

It is anticipated that a first main paper from the Phase 2 project will be published in late 2009.

Further details will be posted here in the coming months.

In addition, in the course of the Phase 2 project, the AGP has been acknowledged in the following publications:

CLICK HERE

1.2 Project research plan

This three-year project will include the following main studies:

  • Complete-genome association analyses on a new sample of 3,000 AGP families (simplex and multiplex families).
  • Analysis of the trait-based subsets of autism, to detect linkage, refine linkage regions, and develop genotype-phenotype relationships.
  • Fine-mapping of the linkage regions identified in AGP Phase 1; and
  • Evaluation of candidate genes.

The first stage of the Phase 2 project - Stage 1 - is now completed:

  • Over 1,500 AGP families have been genotyped on the Illumina 1M beadchip, which enables the genotyping of over one million SNPs in each sample.
  • Subsequently, association, linkage and CNV analyses have been performed.
  • The results from this study have been submitted for publication and are currently under review.

The second project stage - Stage 2 - is ongoing:

  • A second sample of over 1,500 AGP families is being genotyped on the Illumina 1M beadchip (over half now completed).
  • Subsequently, association, linkage and CNV analyses will be performed in 2010 for the complete Phase 2 sample-set (over 3,000 trios)..
  • It is anticipated that the results from this study will submitted for publication by end 2010.

In addition, analyses of AGP phenotypic data are also ongoing:

  • AGP sites are currently uploading phenotype data for the complete AGP sample-set (over 7,500 families). This includes the following data: ADI, ADOS, IQ, Vinelands, Body Measurements and Family Type.
  • Collaborating AGP sites and currently conducting a number of analyses of this data.
  • It is anticipated that over five publications will result from these studies, by end 2010.

See also:

2. AGP Phase 1 project (2004-2007):

CLICK HERE

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